Full review: all 36 actives, their studies and their EU status, up to date. What changed
ShelfBalance · Longevity
Volume34 / 36
Reviewed3 Nov 2026

Fisetin

Fisetin is a flavonoid, a plant pigment found in strawberries, apples, persimmons and onions.

ExperimentalAdvanced level
Fragaria × ananassa
Downton strawberry (Fragaria). Coloured etching, around 1820. Wellcome Collection, public domain.
Reference dose100mga day
TimingWith a mealWith a meal containing fat.
FormFisetin (flavonoid)
EU statusNot authorised as a novel food in the EU. Other purified flavonoids, such as 98% apigenin, have been considered unauthorised novel foods

100 mg a day in supplements.

01

What it is

It is studied as a senolytic: a compound that might help clear out aged cells, which stop dividing and generate inflammation.

02

What it is used for

The quiz suggests it when your answers justify it. It usually appears with these goals:

03

What the evidence says

Experimental

Early data in people or, mostly, from the laboratory. It only appears at the advanced level, and we say so.

Almost all the evidence is preclinical (animals and cells). There are human trials under way, some on joint health, with no established clinical results.

YearWhat was studiedWhat was foundSource
2018Cellular ageingStudy in mice and human tissue: of 10 flavonoids, fisetin reduced aged cells the most, and it extended the lifespan and healthspan of older mice. It is not a trial in people. Yousefzadeh et al.EBioMedicine
2026In peopleProtocol of a trial with 100 mg a day for 7 weeks in healthy adults aged 50 or over, to measure inflammation and safety. No results yet. Tavenier et al.Basic & Clinical Pharmacology & Toxicology
04

What to look for on the label

  • “Senolytic” protocols with high intermittent doses are under investigation: do not copy them on your own.
05

Precautions

  • It may interact with anticoagulants and other medicines.
  • Limited human safety data.
  • No confirmed authorisation as a novel food in the EU.
06

Where to find it

We do not link to any: fisetin has no confirmed authorisation as a novel food in the EU. There are 100 mg products in shops outside the EU; we will link to them if it is confirmed.

We link to the shop; we do not sell anything. Today we earn no commission on any link. If we ever do, the link will say so and the selection will not change: the label decides. Labels checked on 2 November 2026; check the one on the pack before you buy. All these shops deliver to the EU; some of their pages open in Spanish. How we are funded.

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Profile reviewed on 3 November 2026. Sources: EFSA, Regulation (EU) 432/2012 and published studies. Image: Downton strawberry (Fragaria). Coloured etching, around 1820. Wellcome Collection, public domain.

General information based on published scientific evidence and EU law. Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle, and are not intended to diagnose, treat or prevent any disease.

Do not exceed the daily dose stated on each product. If you take medication, have a medical condition or have any doubts, ask your doctor or pharmacist.