Siberian rhubarb ERr 731®
Siberian rhubarb (Rheum rhaponticum) is a relative of garden rhubarb.
4 mg of extract a day.
What it is
Its root contains plant compounds that act selectively on oestrogen receptors. The standardised extract ERr 731 has been used for decades in Germany for wellbeing during perimenopause.
What it is used for
The quiz suggests it when your answers justify it. It usually appears with these goals:
What the evidence says
Trials in people that point the same way, but still few, small or funded by the manufacturer.
12-week clinical trials in perimenopausal women showed fewer hot flushes and better wellbeing compared with placebo. Most come from the same research group.
| Year | What was studied | What was found | Source |
|---|---|---|---|
| 2006 | Hot flushes and wellbeing | 12-week trial with 109 perimenopausal women: it reduced symptoms on the MRS II scale and, from 4 weeks, the number and intensity of hot flushes compared with placebo. No differences in endometrial biopsies. | Heger et al.Menopause |
| 2009 | Long-term use | Observational follow-up of the same women for up to 96 weeks: symptoms kept falling and there were no adverse effects related to the extract. | Hasper et al.Menopause |
| 2024 | The review | Meta-analysis of 4 high-quality trials with 390 women: it reduced the menopause symptom score compared with control. The authors call for more trials because of variability between studies. | Dubey et al.Journal of Biomedical Research |
| 2025 | Breast safety | Observational study using German gynaecologists’ medical records: the 5,686 women prescribed ERr 731 had no more breast cancer diagnoses than those who did not take it or those on hormone therapy. Being retrospective, it cannot rule out other factors. | Heger et al.Breast Cancer Research and Treatment |
What to look for on the label
- Exactly the ERr 731® extract: it is the only one with clinical trials.
Precautions
- If you have had a hormone-dependent cancer (breast, uterus, ovary) or are on hormone therapy, do not take it without asking first.
Where to find it
Products whose label meets what this profile asks for: form, dose per serving and nothing that contradicts it. Three at most: quality of the active comes first and, among the best, we look for one option in each price range. We choose by composition, not by who pays. The shops are European or ship to Europe.
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iHerbShips from the US, VAT included€€€High endMetagenics
Estrovera® (ERr 731®)
4 mg of ERr 731® extract per tablet
For the reference dose1 tabletView at iHerb (opens in a new tab)Meets the criteria.
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iHerbShips from the US, VAT included€BudgetSolgar
Menopause Relief (ERr 731®)
4 mg of ERr 731® extract per tablet
For the reference dose1 tabletView at iHerb (opens in a new tab)Meets the criteria. Also contains 28 mg of saffron extract (affron®): bear this in mind if you already take it.
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Life ExtensionShips from the Netherlands€€Mid rangeLife Extension
Menopause Relief
4 mg of Rheum rhaponticum root extract per tablet
For the reference dose1 tabletView at Life Extension (opens in a new tab)With caveats. It states the ERr 731® standardisation (rhaponticin and desoxyrhaponticin), but the label does not name it.
We link to the shop; we do not sell anything. Today we earn no commission on any link. If we ever do, the link will say so and the selection will not change: the label decides. Labels checked on 2 November 2026; check the one on the pack before you buy. All these shops deliver to the EU; some of their pages open in Spanish. How we are funded.
Nearby in the library
Is it for you?
The quiz decides from your answers, not from a profile.
Profile reviewed on 3 November 2026. Sources: EFSA, Regulation (EU) 432/2012 and published studies.
General information based on published scientific evidence and EU law. Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle, and are not intended to diagnose, treat or prevent any disease.
Do not exceed the daily dose stated on each product. If you take medication, have a medical condition or have any doubts, ask your doctor or pharmacist.